Biomedical Research
Research Award Programs
Funding great research begins with a focus on people and projects. Our Research Roadmap guides our work to address the critical knowledge gaps, advance discovery, and encourage collaboration within the single ventricle field and beyond.
We offer funding opportunities to support academic and clinical investigators to pursue relevant topics to single ventricle heart disease. Our programs aim to foster outstanding science across disciplines, fields, and career stages — and provide resources for our awardees to succeed.
Research Programs
CLOSED
Catalyst to Independence Award
Support for the next generation of scientists means investment in the future of the field.
The Additional Ventures Catalyst to Independence Award is a transition award that supports the next generation of researchers, catalyzing their careers and efforts to solve the biggest questions in single ventricle heart disease and related fields.
Award Amount
Up to $1M over up to 5 years
Eligibility
Applicants must have earned a PhD, MD, DO, or doctoral equivalent more than 1 year prior to the application due date.
CLOSED
Single Ventricle Research Fund (SVRF)
The Single Ventricle Research Fund (SVRF) is an annual research award program that supports foundational research to improve our mechanistic understanding of single ventricle congenital heart disease through multi-year, high-impact grants. This year, the SVRF will consider applications to both the Independent Investigator and Career Development Tracks, providing up to $600,000 and $300,000, respectively, to support direct costs over a three-year award period.
In its fifth cycle, the SVRF is hosting an open call, and welcomes any research with relevance to single ventricle. Resubmissions from previous cycles will also be accepted.
Award Amount
Up to $600,000 in direct costs to be utilized over (3) years for independent investigator track awards. Career Development track awards are eligible for up to $300,000 in direct costs.
Eligibility
Principal Investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates)
CLOSED
AHA/AV Collaborative Sciences Awards in Single Ventricle
Together, the American Heart Association (AHA) and Additional Ventures (AV) have established the AHA/AV Collaborative Sciences Awards in Single Ventricle Heart Disease (CSAs) to support multidisciplinary, multi-institutional research teams addressing key knowledge gaps in the clinical sequelae of single ventricle heart disease and its treatment paradigm.
We encourage a forward-thinking approach to research that is not constrained by long-held hypotheses and dogma, and that is conducted in an environment of trust. We seek to establish a multidisciplinary network of approximately five teams who are enthusiastic about working transparently in a highly collaborative network – a team of teams sharing related, yet unique scientific goals, who prioritize innovation over safe bets, and who are willing to risk testing unconventional ideas. In addition to generous research funds, the CSAs provide dedicated project management support for granted teams, as well as community development support through all-expense- paid biannual meetings and other networking opportunities.
Award Amount
Up to $2.25M direct costs to be utilized over 3 years
Eligibility
Each team should consist of two to four members, including co-PIs with expertise from at least two different disciplines.
CLOSED
Expansion Award
Our Expansion Award enables teams to add new single ventricle–focused approaches and directions to their current work by providing a one-time grant of $50,000. This small but mighty grant is open to both new and established investigators within the single ventricle research community – and has an efficient submission and award process spring-boarding these studies forward, faster.
Award Amount
Up to $50,000 for one year
Eligibility
Principal Investigator(s) (PIs) who hold doctoral degrees (e.g., PhD, MD, PsyD, or equivalent) and are listed as a PI on a parent grant.
CLOSED
Life Sciences Research Foundation: Postdoctoral Fellowship
We believe in supporting the next generation of scientists. We partner with the Life Sciences Research Foundation to support outstanding postdoctoral fellows who are making waves in basic science and advancing fundamental knowledge. Interested fellows should apply through the LSRF website.
Award Amount
$67,000 per fellow per year for three (3) years
Eligibility
Applicants must apply within 5 years of receiving their PhD or MD degree
Funded Studies
Since 2020, we have committed over $43M in direct research support through our award programs. Our grant programs are changing the game by making big and bold investments in specific research questions. They are thoughtfully designed to reimagine the future by reexamining processes to maximize our impact on both people and projects.
Elucidation of the Mechanisms Underlying the Development and Progression of Fontan Associated Liver Disease (FALD)
Investigator Breuer, Christopher
Organization Research Institute at Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Model Organism Development
The DEFEND Trial: Dapagliflozin or Empagliflozin for Fontan Exercise, QOL and MitochoNDrial function
Investigator Miyamoto, Shelley
Organization University of Colorado Anschutz Medical Campus
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Correcting Latent Mechanisms that Underlie Neurodevelopmental Disorders Associated with Congenital Heart Disease
Investigator Gifford, Casey
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
PULSE-SVA Network: Personalized Understanding from Linked Simulations & Electrophysiology in Single Ventricle Arrhythmia
Investigator Deschenes, Isabelle
Organization The Ohio State University
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Consequences of Impaired T Cell Homeostasis in Single Ventricle Congenital Heart Disease
Investigator Nakano, Stephanie
Organization University of Colorado Anschutz Medical Campus
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Assembling 3D human blood vessels to vascularize engineered heart tissues
Investigator Lay Teng Ang
Organization Stanford University
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Defining Neural Crest Regulatory Networks and Lineages in Outflow Tract Development
Investigator Sanjeev Ranade
Organization Gladstone Institutes
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Cardiac Organoid Models of Hypoplastic Left Heart Syndrome
Investigator Hananeh Fonoudi
Organization Northwestern University
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Capturing mechanisms of TBX5 haploinsufficiency underlying ventricular heart defects
Investigator Zoe Grant
Organization Gladstone Institutes
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Investigation of the G9a/GLP histone methyltransferase complex in cardiac specification and identity maintenance during normal heart development and single ventricle disease
Investigator Diana Fulmer
Organization University of Pennsylvania
Focus Area Disease Etiology
Strategic Topic Outcome Origins
A patient-specific workflow for prospective patch design in aortic arch reconstruction
Investigator Shannen Kizilski
Organization Boston Children's Hospital
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
Role of FOXO Signaling in Hypoplastic Left Heart Syndrome
Investigator Diwakar Turaga
Organization Baylor College of Medicine
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Building a 3D Bioprinted Model of Embryonic Heart Valve Morphogenesis Featuring Endocardial and Myocardial Cross-talk
Investigator Jaci Bliley
Organization Carnegie Mellon University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Back to the Future: Expanding Opportunities in Pediatric ABO-Incompatible Heart Transplantation
Investigator Lori West
Organization University of Alberta
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Ex situ heart perfusion for optimization of pediatric donor organ utilization: feasibility and methods
Investigator Darren Freed, Jennifer Conway
Organization Stollery Children's Hospital, University of Alberta
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Novel Approaches to Improve the Availability and/or the Quality of Pediatric Donor Hearts
Investigator James Reynolds
Organization Case Western Reserve University and University Hospitals
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Can HLA data be used to support Precision Medicine in Pediatric Heart Transplantation? An exploratory analysis
Investigator David Rosenthal
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
The impact of Fontan circulatory failure, frailty, and resilience on heart failure and transplant outcomes
Investigator Kurt Schumacher, Melissa Cousino
Organization University of Michigan
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Single-cell multi-omic profiling of the developing heart to map the regulatory wiring and identify the genetic etiology of single ventricle defects
Investigator Jesse Engreitz
Organization Stanford University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Combination proteomic and metabolic fingerprinting: a multi-omic approach to understanding longitudinal pulmonary vascular development in patients with single ventricle heart disease
Investigator Benjamin Frank, Jesse Davidson, & Michael DiMaria
Organization University of Colorado Denver/Children’s Hospital Colorado
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Deciphering the splicing code in cardiac progenitor cells
Investigator Susan Liao, Oded Regev
Organization New York University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
A pilot biorepository of patient-specific induced pluripotent stem cells for studying pulmonary atresia with intact ventricular septum
Investigator Mingtao Zhao, Vidu Garg, Karen Texter
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Characterization of exercise induced cardiac alterations in the Fontan Fitness Intervention Trial using cardiac MRI (F-FIT MRI Substudy)
Investigator Rachael Cordina
Organization University of Sydney
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Optimized metabolic biomarker detection for the development of heart failure diagnostic in single ventricle patients
Investigator Ronald Mark Payne, Thomas O'Connell
Organization Indiana University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Expanding the FORCE: Novel 3D Echocardiogram-Based Analysis of Ventricular Function in Single Ventricle Fontan Patients
Investigator David Harrild, Rahul Rathod
Organization Boston Children's Hospital
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
Novel Neuroimaging based Machine Learning Applications for Risk Stratification of Neurocognitive Deficits in HLHS Patients
Investigator Ashok Panigrahy, Rafael Ceschin
Organization University of Pittsburgh
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
“Single Ventricle Circulation”: Advancing a clinical decision support tool for single ventricle management
Investigator Richard Figliola, Tain-Yen Hsia
Organization Clemson University, Arnold Palmer Hospital for Children
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Analysis of Cellular Metabolic Function in Single Ventricle Heart Disease
Investigator Anastacia Garcia, Shelley Miyamoto
Organization University of Colorado Anschutz Medical Campus
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Expanded nucleotide sequencing for phenotypic mapping of cardiogenic neighborhoods
Investigator Jonathan Butcher
Organization Cornell University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Gene-environment interactions and single ventricle congenital heart disease
Investigator Duncan Sparrow
Organization University of Oxford
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Role of inflammation and flow in pulmonary arteriovenous malformations
Investigator Andrew Spearman
Organization The Medical College of Wisconsin
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Proteomics Analyses of Proteasome Factors in Zebrafish Heart Development
Investigator Lisa Maves
Organization Seattle Children’s Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Deep Learning and Physics Informed Neural Networks to Advance Single Ventricle Atrioventricular Valve Modeling
Investigator Matthew Jolley
Organization Children’s Hospital of Philadelphia
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Spatial Transcriptomics Investigation of Pediatric HLHS Myocardium
Investigator Diwakar Turaga
Organization Texas Children’s Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Precision Therapy for Endocardial Fibroelastosis
Investigator Ingeborg Friehs
Organization Boston Children’s Hospital
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics
Investigator Jian Shu
Organization Massachusetts General Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining cell specific roles of RBFOX2 in cardiovascular development and HLHS
Investigator Muge Kuyumcu-Martinez
Organization University of Texas Medical Branch at Galveston
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Predicting Cardiac Dysfunction and Fontan Failure in Single Ventricle Patients
Investigator Andrew McCulloch
Organization University of California, San Diego
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Exploratory In Vitro Study of Contractile Conduit Potential to Reverse the Fontan
Investigator Alison Marsden
Organization Stanford University
Focus Area Functional Cures
Strategic Topic
Establishment of an animal model of HLHS in Switzerland – Expansion of the parent award analysing late fetal hemodynamics using advanced MR techniques
Investigator Walter Knirsch
Organization University Children’s Hospital Zurich
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Transfer learning to map gene networks driving Hypoplastic Left Heart Syndrome
Investigator Christina Theodoris
Organization Gladstone Institutes
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Understanding and reducing sequelae associated with single ventricle physiology from birth
Investigator Jay Humphrey
Organization Yale University
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
CRISPRa/CRISPRi in hPSC-derived cell-types to accelerate SVD modeling and therapy
Investigator Kyle Loh
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Elucidating Mechanisms of Hypoplastic Left Heart Syndrome Using Cardiac Organoids and Single-Cell Analysis
Investigator Joseph Wu
Organization Stanford University
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Cardiac micro-organ model of single ventricle heart disease
Investigator Kevin Costa
Organization Icahn School of Medicine at Mount Sinai
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
A novel imaging-modelling software tool to predict future neoaortic remodelling in Hypoplastic Left Heart Syndrome
Investigator Adelaide de Vecchi
Organization King’s College London
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Mechanisms of ventricular hypertrophy in vitro and in vivo
Investigator Dylan Burnette
Organization Vanderbilt University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Development of a Regenerative Therapy for Single Ventricle Disease
Investigator Hina Chaudhry
Organization Icahn School of Medicine at Mount Sinai
Focus Area Functional Cures
Strategic Topic
Establishing genotype-phenotype correlations and patient-specific drug responses for hypoplastic left heart syndrome with engineered heart-on-a-chip systems
Investigator Megan McCain
Organization University of Southern California
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Subpulmonary assist device with magnetically levitated pump for Fontan circulation
Investigator Iki Adachi
Organization Texas Children’s Hospital
Focus Area Functional Cures
Strategic Topic
FORCE: Fontan Outcomes Registry using CMR Examinations
Investigator Rahul Rathod
Organization Boston Children's Hospital
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
ACTION: Advanced Cardiac Therapies Improving Outcomes Network
Investigator Angie Lorts
Organization ACTION
Focus Area Data & Analytics Infrastructure
Strategic Topic Harmonized Data & Analytics Platform
FON: Fontan Outcomes Network
Investigator Jack Rychik and Sasha Opotowsky
Organization FON
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
Elucidating mechanisms of ventricular hypoplasia in pulmonary atresia with intact ventricular septum (PA-IVS) using patient-derived induced pluripotent stem cells (iPSCs)
Investigator Mingtao Zhao, Vidu Garg
Organization Nationwide Children's Hospital
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Uncovering the etiology of hypoplastic left heart syndrome using a novel frog model
Investigator Shuyi Nie
Organization Coulter BME
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Mapping the regulatory wiring of heart development to identify the genetic etiology of single ventricle defects
Investigator Jesse Engreitz
Organization Stanford
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Unlocking our Regenerative Capacity: Elucidating the Role of LYST on Neotissue Formation in Tissue Engineered Constructs
Investigator Richard Wilson, Christopher Breuer
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Ventricle chamber formation in mouse models of SV
Investigator Benoit Bruneau
Organization Gladstone Institutes
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
In-utero Left Ventricular Filling & Its Impact on Chamber Growth and Maturation: mechanistic insights into pathogenesis of HLHS and physiological basis for fetal interventions
Investigator Muralidhar Padala
Organization Coulter BME
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Using Audio Characteristics of Systemic to Pulmonary Connections in Functionally Single-Ventricle Infants as a Non-invasive Measure of Pulmonary Blood-flow Parameters
Investigator Saidie Rodriguez
Organization Coulter BME
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Development of a protocol to risk stratify individuals with single ventricle congenital heart disease using deep phenotyping and genome sequencing
Investigator Kim McBride, Peter White
Organization Nationwide Children's Hospital
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
Development of a tissue engineered trans-catheter heart valve for use in the endovascular repair of single ventricle cardiac anomalies in utero
Investigator Lakshmi Prasad Dasi
Organization Coulter BME
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
A 3D Printed Vascularized Cardiac Biopump to Assist the Fontan Circulation
Investigator Mark Skylar-Scott
Organization Stanford
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Reprogramming of Right Ventricle Cardiomyocytes to be Left Ventricular-lIke
Investigator Deepak Srivastava, Katie Pollard
Organization Gladstone Institutes
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Device for Mechanically Induced Ventricular Growth in Single Ventricle Patients
Investigator Alison Marsden
Organization Stanford
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Machine Learning-Based Boundary Conditions for Fontan Surgical Planning
Investigator David Frakes
Organization Coulter BME
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
Lymphatic failure and genetic susceptibility; role in end-organ dysfunction in single ventricle patients
Investigator Yoav Dori, Daniel Licht, Hakon Hakonarson
Organization Children's Hospital of Philadelphia
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Origins and Burden of Multi-Organ Fibrosis in Patients with Single Ventricle Heart Disease
Investigator Elizabeth Goldmuntz, Jack Rychik
Organization Children's Hospital of Philadelphia
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Mechanisms of ventricle chamber formation in mouse models of single ventricle
Investigator Benoit Bruneau, Deepak Srivastava, Katie Pollard
Organization Gladstone Institutes
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Deciphering the Embryonic Stem Cell Splicing Code
Investigator Susan Liao
Organization NYU Courant Institute of Mathematical Sciences
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Engineering a self-deliverable CRISPR-Cas9 system for precise genome editing
Investigator Kai Chen
Organization University of California, Berkeley
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
The neural circuits underlying cardiac function
Investigator Luis Hernandez-Nunez
Organization Harvard University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
A Multifaceted Approach to Understanding and Optimizing Single Ventricle Hemodynamics; Leveraging the Combined Power of In vitro Simulators, Computational Modeling and Clinical Imaging to Develop Non-Invasive Biomechanical Interventions.
Investigator Ellen Roche
Organization Massachusetts Institute of Technology
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Maternal Blood Biomarker Discovery for Predicting Ventricular Growth in Human Fetuses with PA-IVS
Investigator Mingtao Zhao
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Early Detection
A Liquid Biopsy of myocardial signaling in children with single ventricle heart failure
Investigator Sushma Reddy
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Targeting mitochondrial dysfunction to prevent heart failure in single ventricle congenital heart disease
Investigator Sean Wu
Organization Stanford University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Immunophenotyping in Pediatric Patients with Single Ventricle Congenital Heart Disease: Connecting Inflammatory and Immune Dysregulation with Outcomes
Investigator Stephanie Nakano
Organization University of Colorado Anschutz Medical Campus
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Peripheral Mononuclear Cells as Biomarkers for Myocardial Metabolic Function in Single Ventricle Congenital Heart Disease Patients
Investigator Anastacia Garcia
Organization University of Colorado Anschutz Medical Campus
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Understanding and Reducing Sequelae Associated with Single Ventricle Physiology
Investigator Jay Humphrey
Organization Yale University
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
A Pilot Study to Assess the Feasibility and Safety of Targeting Mean Arterial Pressure to Reduce Intraoperative Hypotension and Improve Neurodevelopmental Outcomes in Neonates Undergoing Cardiothoracic Surgery
Investigator Kenneth Brady
Organization Ann & Robert H. Lurie Children’s Hospital of Chicago
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Precision Therapy for Endocardial Fibroelastosis
Investigator Lili Zhang
Organization Boston Children's Hospital
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Cerebrovascular Integrity in Fontan Patients
Investigator John Wood
Organization Children's Hospital of Los Angeles
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Blood Viscosity, a Critical Determinant of Pulmonary Vascular Resistance in the Fontan Circulation
Investigator Jon A. Detterich
Organization Children's Hospital of Los Angeles
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Transforming Mental Health Outcomes in Single Ventricle Heart Disease
Investigator Nadine Kasparian
Organization Cincinnati Children’s Hospital
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Enhanced External Counterpulsation in Patients with Fontan Circulation
Investigator Fred Wu
Organization Harvard Medical School
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Clinical Prediction Tool for Neurodevelopmental Outcome in Single Ventricle Heart Disease
Investigator Caitlin Rollins
Organization Boston Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Development of a metabolic biomarker panel to identify SV patients at risk for heart failure
Investigator Ronald Mark Payne
Organization Indiana University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Nitric Oxide Pathway Biomarkers to Assess Prognosis and Individualize Care in Fontan Patients
Investigator Ari Cedars
Organization Johns Hopkins University
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
The Injection-Jet Powered Fontan Circulation: A Novel Bridge and Destination Therapy for the Failing Fontan
Investigator William DeCampli
Organization University of Central Florida
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Hippo/YAP signaling and genetic networks of HLHS
Investigator James Martin
Organization Baylor College of Medicine
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Transcriptional and morphogenetic signatures of congenital heart disease pathways
Investigator Alessandro Bertero
Organization University of Turin (Università degli Studi di Torino, UNITO)
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Modeling human heart morphogenesis and congenital heart disease with bioreactor-derived cardiac organoids
Investigator William Pu
Organization Boston Children's Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Embryological origin of functional single ventricles in the heterotaxy syndrome
Investigator Sigolène Meilhac
Organization Institut Pasteur and Université de Paris
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Gene-regulatory impact of Wnt signaling in ventricle formation
Investigator Christian Mosimann
Organization University of Colorado Anschutz Medical Campus
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Origin of Cardiac Pacemaker Cells
Investigator Vasanth Vedantham
Organization University of California, San Francisco School of Medicine
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanisms of Left Ventricle Heart Development
Investigator Neil Chi
Organization University of California, San Diego
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining cell-specific roles of Rbfox2 in cardiovascular development
Investigator Muge Kuyumcu-Martinez
Organization University of Virginia School of Medicine
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanisms of Early Ventricular Lineage Specification
Investigator Nicole Dubois
Organization Icahn School of Medicine at Mount Sinai
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanobiological mechanisms of cardiac morphogenesis
Investigator Stephanie Lindsey
Organization University of California, San Diego
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mitochondrial citrate transport: A novel, potentially druggable link to hypoplastic right heart syndrome
Investigator Jennifer Kwong
Organization Emory University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Leveraging induced pluripotent stem cells to define the developmental drivers of hypoplastic left heart syndrome
Investigator Andrew Landstrom
Organization Duke University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Collective Neighborhood Signaling Driving Ventricular Growth, Maturation, and Pathogenesis
Investigator Jonathan Butcher
Organization Cornell University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Gene-environment interactions and single ventricle congenital heart disease
Investigator Duncan Sparrow
Organization University of Oxford
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics
Investigator Jian Shu
Organization Massachusetts General Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining Novel Roles for Proteasome Factors in Heart Development
Investigator Lisa Maves
Organization Seattle Children's Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
A reference map of enhancers during human fetal heart development to understand the genetic etiology of single ventricle diseases
Investigator Jesse Engreitz
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Left/right asymmetry in cardiac neural crest contributions to the heart
Investigator Marianne Bronner
Organization California Institute of Technology
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Discovering Biomechanical Phenotypes Caused by CHD-linked Gene Mutations
Investigator Stuart Campbell
Organization Yale University
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Neonatal cardiac stem cell-derived proteins induce cardiac regeneration in HLHS
Investigator John Coles
Organization The Hospital for Sick Children
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
HiP-CTxSVD: Deep-Phenotyping of Single Ventricle Disease (SVD) by Synchrotron-based Hierarchical Phase Contrast Tomography (HiP-CT)
Investigator Andrew Cook
Organization University College London
Focus Area Disease Etiology
Strategic Topic Model Organism Development
A comprehensive and non-invasive assessment of skeletal muscle in adolescents with single ventricle circulation
Investigator Daniel Forsha
Organization The Children's Mercy Hospital
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Understanding Valve Abnormalities in Pulmonary Atresia with Intact Ventricular Septum
Investigator Mingxia Gu
Organization Children's Hospital Medical Center
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Noonan syndrome as a model to decipher the molecular mechanisms underlying human congenital heart defects
Investigator Fabrice Jaffré
Organization Weill Medical College of Cornell University
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Computational Modeling of the Atrioventricular Valve Repair Single Ventricle Patients with Atrioventricular Canal
Investigator Matthew Jolley
Organization The Children's Hospital of Philadelphia
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
A Fetal Lamb Model of Single Ventricle Defect by In Utero Underloading of the Left Ventricle
Investigator Muralidhar Padala
Organization Emory University
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Mechanistic understanding of Fontan associated liver disease with single-cell multiomics
Investigator Liming Pei
Organization The Children's Hospital of Philadelphia
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Social Determinants of Health As Targetable Modifiers Of Early Brain Health Outcomes In Single Ventricle Heart Defect
Investigator Vidya Rajagopalan
Organization Children's Hospital Los Angeles
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
The Role of RNA-Binding Protein QKI in Cardiogenesis
Investigator Weinian Shou
Organization Indiana University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Fibrosis, inflammation and thrombosis in Fontan Failure: The FIT-Fontan study
Investigator Alexander Van De Bruaene
Organization Catholic University of Leuven (Katholieke Universiteit Leuven, KU Leuven)
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Osmotic control of cell identity and shape during zebrafish heart valve formation
Investigator Julian Vermot
Organization Imperial College of Science, Technology and Medicine
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Role of the Pcbp1-Aars2 axis in the regulation of ventricular non-compaction and congenital heart defects
Investigator Da-Zhi Wang
Organization University of South Florida
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Cellular, Transcriptional, and Signaling Landscape of the Resilient and Failing Single Ventricle
Investigator Kory Lavine
Organization Washington University in St.Louis
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Characterizing the dysregulation of human cardiac neural crest cells in single ventricle disease
Investigator Jason Tchieu
Organization Cincinnati Children's Hospital Medical Center
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Early life hypoxia in patients with single ventricle heart disease impairs T cell function
Investigator Sarah Henrickson
Organization The Children's Hospital of Philadelphia
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Elucidating etiologies of HLHS and HRHS using patient-specific cardioids
Investigator Mingtao Zhao
Organization The Research Institute at Nationwide Children's Hospital
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Functional micro-organ model of human heart tube development and single ventricle disease
Investigator Kevin Costa
Organization Icahn School of Medicine at Mount Sinai
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Hypoplastic left heart syndrome animal model with in-utero fetal lamb by mitral inflow obstruction
Investigator Daisuke Onohara
Organization The Research Institute at Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Model Organism Development
Increasing Transplant Opportunities for Single Ventricle Patients: Creating the Universal Donor
Investigator Jennifer Conway
Organization Governors of the University of Alberta
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Investigating a Placental Etiology of Single Ventricle Congenital Heart Disease in Humans using Advanced MRI and a Multiomics Approach
Investigator Rachel Leon
Organization The University of Texas Southwestern Medical Center (UT Southwestern)
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Longitudinal analysis of single ventricle PAVM pathophysiology
Investigator Andrew Spearman
Organization The Medical College of Wisconsin, Inc.
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Longitudinal Evaluation and Assessment of Fontan Lymphatics Examining Tissue (LEAFLET) Study
Investigator Gabriele Egidy Assenza
Organization IRCCS Azienda Ospedaliero-Universitaria di Bologna
Focus Area Clinical Sequelae
Strategic Topic Longitudinal Clinical & Imaging Data
Mechanically Assisted Establishment of Biventricular Physiology for Failing Fontan Circulation
Investigator Iki Adachi
Organization Baylor College of Medicine
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Non-contact flow sensors for pediatric vascular shunts
Investigator Ellis Meng
Organization University of Southern California (USC)
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Structure-function relationship in vascularized left ventricle
Investigator Milica Radisic
Organization University Health Network
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Unraveling the Function of TGFß in Myocardial and Valve Deficiency in Ebstein’s Anomaly
Investigator Guang Li
Organization University of Pittsburgh
Focus Area Disease Etiology
Strategic Topic Deep Phenotype-Genotype
Functional Characterization of Patient-Specific Pathogenic Variants in Single Ventricle Congenital Heart Disease
Investigator Daniel Quiat
Organization Boston Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Deciphering RNA-based regulatory mechanisms during cardiomyocyte differentiation
Investigator Susan Liao
Organization New York University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
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